As I had mentioned earlier, I had decided not to commit the residents to a lecture the second day we were here, so we all had an extra half-hour of much needed sleep. Our normal schedule is having morning report at 8:00 am on weekdays with educational lectures at 7:30 am on Tuesday and Thursday. There is no morning report on Saturday, and we typically don’t work on Sundays. Clinic normally runs from 8:30 am to 4:30 pm mzungu (stranger) time, or 2:30 to 10:30 Swahili time. As we are on the equator here, which means that the sun typically rises and sets within a very narrow window of time, 6:00 am in mzungu time is the same at 0:00 in Swahili time, and 6:00 pm is the same as 12:00 in Swahili time. It’s really not very confusing and most Maasai as well as many other Tanzanians in the rural areas use these time designations such that the posted time for most businesses in Karatu will post both of these hours on their door. Swahili time really doesn’t use am and pm but rather refers to each time as being either in the morning, afternoon, or night for orientation.
It was turning out to be a rather slow day in clinic, partially because of the weather (cool rains) as well as the fact that it was our fourth week of clinic, so after some discussion, it was decided that later this afternoon, Annie would take Theandra into town to have her hair braided. Not being someone who has much hair sympathy (as Jill reminds me on a regular basis) nor pays any attention to my coif (hey, I’ve been cutting my own hair since the beginning of the pandemic), I was having a bit of a hard time fully comprehending the extent of the undertaking that was soon to take place. In any event, today seemed to be the perfect day to get this done given the volume of patients and the fact that we’d be able to finish at least on time, if not earlier.
Theandra, who had seen our neurocysticercosis patient in clinic the day before, rounded on him in the ward and found that he was better clinically – he was more alert and more oriented than he had been the day before which was certainly a good sign given the incredible burden of active lesions he had on presentation. Similar to the patient with the hydatid cyst that we had seen several weeks ago, treating these helminthic infections can be tricky as the organisms are massively immunogenic when they are killed, creating a very severe immune reaction that can in itself be the final straw in creating enough edema to herniate.
I decided to reach out regarding this patient to one of my colleagues at Penn, Steve Gluckman, who is a tremendously experienced infectious disease expert and had not only come to FAME with me several years ago, but had also practiced in Botswana for a number of years and had started the Botswana-Penn Partnership back in the early 2000s. I heard back from quickly with the confirmation that our treatment plan was at least correct as far as the consensus on treating cysticercal encephalitis, though he pointed out that there are no controlled trials regarding treatment to date. Given the fact that he was clearly improving, and not getting worse, we decided to stay the course and would watch him for several more days before discharging him.
Meanwhile, to follow up on our young girl with the massive hydatid cyst who we had seen several weeks ago and initially referred her to the neurosurgeon, but unfortunately, her family had taken her home instead to collect the necessary money to pay for surgery. She showed up to KCMC a week ago and was placed on anti-helminthic medication (we hadn’t started her unfortunately as we hadn’t planned the delay in her getting to KCMC) in preparation for surgical excision of the cyst. Hydatid cysts require very special handling as the cyst has to be removed intact without spilling the contents into the surgical site for if this occurs, it will induce a very significant inflammatory response that will create a number of other serious and concerning issues.
We received word that she underwent surgery successfully on Friday with complete removal of the cyst, though apparently, she did have some spillage of the cyst contents into the surgical site. I haven’t heard any updates, but hopefully she will do well. We heard from Dr. Dekker at KCMC who is the neurologist there that cautioned they had lost a patient with a hydatid cyst previously in the postoperative who had a similar issue, so we’ll keep our fingers crossed and pray that she does well and recovers the function of her left side over time. Seeing patients like these with hydatid cysts and neurocysticercosis, conditions that you see infrequently back at home except for in patients who have traveled from endemic regions of the world, really puts things into perspective. Much of the problem here, though, is that patients often come in at advanced stages of their disease due to the lack of access to health care that exists throughout much of the country.
Ashley saw a very fascinating young child today who had come to see us from the Loliondo district which is a region that is far north by the Kenya border and Lake Natron and is perhaps six to seven hours by bus. It is a remote area that has very little other than basic medical services and the region is primarily occupied by the Maasai. I have traveled up there once to spend time at a Thomson Safari camp and visited a hospital in the town of Wasso that had few doctors to care for way too many patients which is far too often the case in these remote regions. The topography, though, is gorgeous and rugged with the two main geologic features being Lake Natron, a saline lake that is a huge flamingo nesting site, and Ol’ Doinyo Lengai, or Mountain of God in Kimaa and is sacred to the Maasai. Ol’ Doinyo Lengai is an active volcano that last erupted in 2007-2008 and is unusual in that its magma is natrocarbonatite which is unusually low in temperature and is highly fluid. Flows of black lava can be seen over most of the volcano and on the lands surrounding it.


The baby who had come from Loliondo was 9 months old and was essentially hypotonic, not having reached any of its gross milestones such as sitting up or rolling over, though it seemed to be very attentive during the examination. The baby was having trouble controlling its head movements and was also reported to have difficult swallowing. On examination, the most significant finding other than its hypotonicity was that it had intact reflexes.


The differential was vast and all we could really check here was a TSH to rule out hypothyroidism, and a CPK to exclude some myopathies. Both of these tests were normal, and we were left with very little to do other than ponder, though we did decide to obtain an EEG the following day despite the fact that the baby seemed cognitively intact. As the family had traveled from Loliondo, they had planned to stay at least a night in town, so we did have the option of bringing her back. Ashley emailed a number of folks at CHOP to see if anyone had any other thoughts, though unfortunately, we had no means of checking for any of those that were suggested such as congenital myasthenia, mitochondrial disorders (her eye movements were normal though), and a vast array of genetic disorders. Without the means to test for any of these, we were at a loss of what we could do to diagnose here, let alone to come up with any treatments other than symptomatic. We did recommend that they see speech therapy at the Monduli rehab facility for their dysphagia and asked them to come back and see us in six months. It was tremendously unsatisfying to say the least.
We finished in clinic with plenty of time for Theandra to depart for the hair salon and Ashley and Laura wanted to accompany her. Annie would have to be there for the entire time to make sure things were being done correctly (this is a service that Annie happily provides us for without her oversight we would certainly run the risk of being taken advantage of) and that Theandra would not be charged a mzungu price which is what typically happens if any of us walks into a shop unaccompanied.
This is not derogatory in any way, just a fact of life here given the vast disparities that exist financially between a society in which the annual income in the Karatu district may be $250-$500 and what our incomes are in the United States. Though it is expected for anyone buying something here to bargain, including the Tanzanians, I have made it a practice never to haggle to the last shilling for whatever they are asking, a few shillings mean tremendously more to them than it does to me. That certainly doesn’t mean paying a totally unreasonable amount of money for something that isn’t worth anything close to what they are asking, but it just means being fair and not needing to feel that you got something for a steal.

I had a FAME board meeting to attend by Zoom from 5-6 pm, so Jill and I planned to drive down to the salon and see how things were going. We arrived at probably about 6:30 and it was clear that Theandra wasn’t even close to being halfway done with her hair, so Laura, Ashley, Jill and I walked the few blocks to the center of town to look around at the huge indoor vegetable market and some of the shops that lined the alleys close by. Karatu seems to come alive after sunset and there were lots of people shopping and walking the streets. The sunset was also particularly colorful and easily visible from the streets we were walking.
It was now dark, and we were walking through the small alleyways of Karatu where I have always felt safe, but it was time to get back to the salon and check on Theandra. When we arrived, she still seemed to have an army of workers surrounding her and I’m not certain that they had gotten tremendously further than they were when we had first left for the market. We sat for a while before Annie finally came to us suggesting that we all head home as it was still going to be some time before things wrapped up and we hadn’t yet eaten. Annie would stay there until the entire process was complete and would make sure to get Theandra safely home with Vincent, the taxi driver she uses and who has been driving Jill to the Black Rhino in the mornings. I sat up in the living room patiently (well, kind of) waiting for her to return which she finally did around 9:30 pm – having started by 5:00 pm, that was probably four hours of sitting in a chair for everything to be finished. Thank God that’s not an option for me!





























































































































































































